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  2. Hi, I hope you had a good holiday and a happy new year. Just a short update this week, since as I mentioned last time, New Zealand pretty much closes down from mid-Dec to mid-Jan for the holidays. Things will finally be coming back to life next week. On the science side, the protein from the second fabrication batch that I mentioned in my last update is now in-hand. As the last step of fabrication, we run the dissolved compound through a 0.2 micron filter, which effectively sterilizes it. After that, it can be safely stored at 4C (in a standard refrigerator). The
  3. Hi, Our crowdfunding campaign is now complete. We raised NZ $24,200 (about USD $17,000). Thanks again to those who donated! We have recently completed fabrication of the second batch of our protein, with significantly improved purity and yield. Excellent progress. We are now working on replicating some of the basic antiviral functionality described in the 2011 paper about DRACO. There is a surprising amount of interesting and complex science involved. We are anticipating that several iterations of fabrication and testing may be required. In case you haven't b
  4. Hi, Our crowdfunding campaign is coming down to its last 48 hours. Thanks if you have already donated. In case you haven't had a chance to check out the campaign recently, here's a link: https://donate.kimermed.co.nz/campaign/2/ending-viral-disease Since the last Weekly Update, there have been a couple of new posts in the members only section of the forum: https://forum.kimermed.co.nz/index.php?/forum/15-general-discussion/ If you made a donation more than about a week ago and don't yet have access to that part of the forum, please let me know (more recent
  5. Last week
  6. I caught this story on Oramed which delivers proteins to treat diabetes which are encapsulated and then have increased absorption in the small intesting. Perhaps it might be applicable for VTose. https://jewtube.tv/innovation/israeli-pharmaceutical-developed-the-first-pill-to-treat-diabetes-without-insulin-shots/ https://www.oramed.com/technology/scientific-abstracts/
  7. Earlier
  8. That's encouraging. A low inflammatory diet will minimize immune cytokine damage. Make GcMAF a recommended contraindication as it increases antibody production. If VTose works you shouldn't need it. ME patient antibody production is suppressed anyway by the viral nagalase so it may not end up being a problem. Critical Covid and Nutrition Information for Patients.pdf
  9. Glad to see a group like this exists. Not long ago last year, I read about DRACO and was wondering why it hadn't yet been looked into. Relieved to see that it is now though! For perks, I like the idea of a keychain, magnet, and/or vinyl decal with the company logo on it. However, maybe it could have the small line inside the virus shape changed to look like a dragon, since DRACO is named after them, like this: I also feel a small plush is a great idea but I am unsure about how automation can/will go with those. Hope this helps!
  10. Rick

    Delivery method

    The molecular weight of VTose is roughly 35 kDa. One of the earliest papers about transduction tags showed effectiveness with a protein with a MW of 120 kDa: In vivo protein transduction: delivery of a biologically active protein into the mouse - PubMed (nih.gov) Transport of even larger proteins is undoubtedly possible.
  11. My biggest concern is the chance that immune response that could give a serious anaphylaxis reaction in up to 30% of patients. Granted, it may not occur with VTose but that's a high number. https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)33585-7
  12. What's the molecular weight of the VTose system? What is the largest molecular weight that can be encapsulated into a protein transduction tag? Immune reaction is a major side effect of the injected PTTs. https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)33585-7 I'm not sure if this would be a problem with the oral form as well.
  13. If you can't get that patent there is no way to raise the money to afford to complete the drug approval process.
  14. I see the problem. Maybe a port can be put in temporarily for self injection for a year or so and checked monthly by the patient's primary care practitioner. This is a big hurdle. How often does it need to be injected? Your immediate concerns should be reformulating it for caspase 7 and securing a provisional patent.
  15. Specific treatment protocols is one of the things we will be researching. We certainly will also be putting some effort into trying to develop an oral form. However, proteins are very susceptible to damage and degradation by the digestive system, so it's a challenge. Insulin, for example, which is a relatively small peptide (a short protein), still doesn't have an oral form.
  16. Ok, for a 10 year myalgic encephalomyelitis patient who has to clear years of infected cells what are we looking it? # of injections over what time interval? Can an oral form be developed?
  17. For Rider's study with mice to treat Influenza, he only treated them for a few days. Dosing in humans will depend on a number of factors, such as the type of virus being treated, the severity of the infection, whether there are other viral co-infections, and so on. We are also looking at formulation changes that are intended to influence the required dose. The specifics in this area are one of the many things that we plan to determine during clinical trials.
  18. What kind of VTose dosing duration and schedule are we looking at for injections? My concern is that apoptosis is very intense. I have a treatment worked out, Craysing, that appears effective for combined HHV6 and EBV infection which is administered by mouth and that one appears to be taking 9 months. I think the limiting factor is that it relies on antibodies and can only cover so many cells per day so you get a layer by layer removal of infected tissue. However, if we induce the same amount of total apoptosis within an accelerated time frame, say 3 months, then we have do deal with a much
  19. We've completed the first week of our crowdfunding campaign! Thanks if you have already donated. If you haven't had a chance to donate yet, here's a link: https://donate.kimermed.co.nz/campaign/2/ending-viral-disease Donations of any amount are welcome and appreciated. I've just made the first post in the new members-only section of the forum: Sample antiviral cytopathic effect test results If you aren't a member yet, you can become one by either subscribing on the forum, or by donating NZ $35 (US $23) or more on the crowdfunding site. Note that subscrip
  20. Thank you so much for letting me know. I have backed the campaign. :)
  21. Our Crowdfunding Campaign started today! https://donate.kimermed.co.nz/campaign/2/ending-viral-disease
  22. Our crowdfunding campaign is now live! https://donate.kimermed.co.nz/campaign/2/ending-viral-disease It will run for the next 30 days. Our goal is to raise at least NZ $50,000 (USD $33,000). For donations of $100 or more, you can choose to sponsor a particular virus. The way this works is that you can pick a virus that interests or concerns you from a list, and we will direct 50% of your donation toward research on that virus. We also look at sponsorship as a kind of dollar-weighted vote, to help us prioritize our research. We are also offering discount
  23. Thanks for the suggestion. I was under the impression that USAMRIID only works with US-based companies, but I'll have another look.
  24. Have you considered partnering with USAMRIID? DRACO was initially developed under a grant from DARPA for I assume the purpose of providing a defense against biological warfare agents. UAAMRIID is the primary lab responsible for developing biological defenses. They would be very interested in a broad spectrum antiviral like VTose. They also have a program for cooperating with outside labs, sometimes providing funding. https://www.usamriid.army.mil/extramural.htm
  25. Hi, Just a short update this week, but with some exciting news. First, our crowdfunding campaign will begin on Sun Nov 15! More details as we get closer. In addition, we have started fabricating the first batch of our compound. It's a bit of a process, so it takes a while. This batch will be a relatively small run, but it should produce enough for us to do some testing. Thanks for your continued interest and support. Regards, --Rick Our vision is the end of all viral disease in humans, pets and livestock.
  26. Yes, exactly! We have a few other ideas along similar lines, too.
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